Table 2. Top canonical pathways and molecular functions enriched by DEGs*.
| Canonical pathways | P-value | Ratio | Molecules |
|---|---|---|---|
| Granulocyte Adhesion and Diapedesis | 8.56×10−8 | 33/177 (0.186) | FPR3,IL1A,MMP3,MMP14,MMP13,CCL20,CCL22,CXCL5,IL1R2,CXCL10,HRH1,CCL13,CXCL13,CCL28,MMP11,CXCL17,MMP12,TNFRSF1B,MMP1,TNFRSF11B,CLDN10,SDC1,MMP28,ITGA2,MMP10,ITGAL,SELPLG,C5,ITGB2,ITGAM,IL1RN,CCL18,MMP9 |
| Inhibition of Matrix Metalloproteases | 5.95×10−6 | 12/39 (0.308) | SDC1,MMP28,MMP3,TIMP1,MMP14,MMP10,MMP13,MMP11,MMP12,MMP9,LRP1,MMP1 |
| LPS/IL-1 Mediated Inhibition of RXR Function | 1.16×10−5 | 33/219 (0.151) | IL1A,CHST4,CYP2C9,ABCG1,CYP2C19,IL1R2,ALDH1A1,UST,NR0B2,NR1I2,ALDH3A2,ACSL5,HS6ST2,CHST11,HS3ST1,HS6ST3,GSTA1,LBP,TNFRSF1B,SLCO1B3,ALDH6A1,TNFRSF11B,GSTA2,GSTA4,IL4I1,TLR4,FABP2,SULT1E1,ALDH1L2,IL1RN,NR5A2,GSTO2,SULT1B1 |
| Antigen Presentation Pathway | 2.11×10−5 | 11/37 (0.297) | PSMB9,NLRC5,HLA-A,HLA-DMB,CIITA,HLA-DOB,PSMB8,HLA-F,TAP1,TAP2,TAPBP |
| Complement System | 2.11×10−5 | 11/37 (0.297) | ITGB2,CR1,ITGAM,C4BPB,CFB,C1QC,C6,C1QB,C2,CR2,C5 |
| Leukocyte Extravasation Signaling | 2.56×10−5 | 30/198 (0.152) | RAC2,MMP3,PTK2B,MMP14,MMP13,RHOH,NOX1,TIMP1,CYBB,MMP11,MMP12,MMP1,ACTN1,CLDN10,PIK3C2B,MMP28,ITGA2,MMP10,ITGAL,SELPLG,ITGB2,WIPF1,ITGAM,EDIL3,RAP1GAP,NCF2,PIK3R6,VAV1,MMP9,PRKCB |
* Canonical pathway analysis identified the pathways from the IPA library of canonical pathways that were most significant enriched in differentially expressed genes. Genes with FDR q-value of <0.01 from data set that were associated with a canonical pathway in the Ingenuity Knowledge Base were considered for the analysis. The significance of the association between the data set and the pathway was measured in 2 ways: 1) a ratio of the number of molecules from the data set that map to the pathway divided by the total number of molecules that map to the canonical pathways is displayed. 2) Fisher's exact test was used to calculate a p-value determining the probability that the association between the genes in the observed values and the canonical pathway is explained by chance alone.