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. 2017 Mar 28;8(26):42588–42601. doi: 10.18632/oncotarget.16585

Figure 7. GALNT6 knockdown affects gene expression in ES-2 cells.

Figure 7

(A) Enrichment results of GALNT6 knockdown in ES-2 cells were mapped as networks. Nodes represent enriched gene sets (p < 0.05), and edges represent gene overlap scores between nodes above the threshold (0.5). Node color encodes the enriched significance and node size is proportional to the number of genes which were associated with a given Gene Ontology term. Groups of functionally related Gene Ontology terms are manually identified and labelled with the appropriate terms. Groups with less than four terms are not shown in this map. (B) Quantitative RT-PCR was performed to validate microarray results. Altered expression (fold change) of selected genes upon GALNT6 knockdown in ES-2 cells compared with control. Values less than 1 represent gene downregulation. Results were analyzed from three independent GALNT6 knockdown ES-2 cell groups and their corresponding controls and are presented as mean ± SD.