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. 2017 Mar 29;8(26):42602–42612. doi: 10.18632/oncotarget.16645

Figure 6. The negative correlation between Annexin V and VEGF expression in melanoma.

Figure 6

(A-B) Analysis of Annexin V and VEGF expression levels in normal melanocytes and most melanomas using Harlin melanoma dataset. The results showed a significant decrease of Annexin V levels and a remarkable rise of VEGF levels in most melanomas, compared to the normal group. (Mean ± SEM, n=8, *p<0.05, ****P<0.0001 compared with PBS group). (C-E) Regression analysis of correlation between Annexin V and VEGF expression levels using Harlin, Xu, and Hoek melanoma datasets, respectively. (F) The impact of Annexin V expression levels on the survival rates of melanoma patients using Kaplan Meier plotter. The results suggested that a high expression level of Annexin V tended to indicate an improved prognosis, and vice versa.