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. 2017 Apr 27;8(26):42742–42751. doi: 10.18632/oncotarget.17451

Figure 1. Establishment of trastuzumab-resistant gastric cancer cell line NCI-N87-TraRT.

Figure 1

(A), NCI-N87 and NCI-N87-TraRT cells were treated with an increasing concentration of trastuzumab for 5d. Cell proliferation was then determined by CCK8 assay. Results are shown as the inhibition rate of cell proliferation. Error bars, SD. ***P < 0.001; unpaired Student's t-test. (B), Tumor volume of NCI-N87 and NCI-N87-TraRT tumor xenografts after 4-week treatment with control IgG (10mg/kg, twice a week, intravenously) and trastuzumab (10 mg/kg, twice a week, intravenously). Data are shown as means ± SEM. ***P < 0.001, Mann-Whitney test. (C), Immunoblots comparing major cell signaling changes between NCI-N87 and NCI-N87-TraRT cell lines. Every experiment was repeated 3 times.