Table 3. Diagnostic performance of single or multiple biomarkers for the detection of pancreatic cancer.
| Marker | % Sensitivity at fixed 90% Specificity | |||||
|---|---|---|---|---|---|---|
| Pancreatic cancer vs. | Early pancreatic cancer vs. | |||||
| Healthy subjects + Pancreatitis | Healthy subjects | Pancreatitis | Healthy subjects + Pancreatitis | Healthy subjects | Pancreatitis | |
| CA19-9 | 79.4 | 84.9 | 69.1 | 88.7 | 93.6 | 71.0 |
| APOA4 | 27.1 | 16.4 | 51.4 | 32.3 | 22.6 | 50.0 |
| APOC3 | 35.3 | 35.3 | 35.3 | 29.0 | 11.3 | 29.0 |
| IGFBP2 | 30.5 | 30.5 | 30.5 | 35.5 | 35.5 | 35.5 |
| TIMP1 | 17.7 | 14.7 | 21.6 | 17.7 | 14.5 | 22.6 |
| CA199+APOA4 | 73.3 | 84.9 | 73.3 | 29.0 | 12.9 | 75.8 |
| CA199+APOC3 | 71.6 | 84.3 | 71.6 | 40.3 | 40.3 | 72.6 |
| CA199+IGFBP2 | 71.9 | 84.3 | 71.9 | 8.1 | 9.7 | 77.4 |
| CA199+TIMP1 | 72.6 | 84.3 | 72.6 | 40.8 | 41.4 | 75.8 |
| CA199+APOA4+APOC3 | 81.9 | 82.9 | 74.0 | 21.0 | 14.5 | 74.2 |
| CA199+APOA4+IGFBP2 | 80.1 | 81.9 | 79.1 | 29.0 | 12.9 | 80.7 |
| CA199+APOA4+TIMP1 | 43.5 | 42.5 | 79.5 | 27.4 | 25.8 | 85.5 |
| CA199+IGFBP2+TIMP1 | 78.4 | 81.2 | 74.0 | 16.1 | 16.1 | 74.2 |
Abbreviations: CA 19-9, carbohydrate antigen 19-9; APOA4, apolipoprotein A-IV; APOC3, apolipoprotein CIII; IGFBP2, insulin-like growth factor binding protein 2; TIMP1, tissue inhibitor of metalloproteinase