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. 2017 May 11;8(26):42997–43007. doi: 10.18632/oncotarget.17792

Figure 6. [225Ac]Pep-1L causes double strand DNA breaks, GBM cytotoxicity and reduces cell proliferation in orthotopic U251 GBMs.

Figure 6

Histological analysis of GBMs from mice treated with [225Ac]Pep-1L showed (A) increased γH2A.X sub-nuclear accumulation indicating fatal double strand DNA breaks, (B) lower expression of Ki67 indicating reduced tumor proliferation and progression, thereby supporting bioluminescent data and (C) greater internalization of propidium iodide indicating tissue necrosis/apoptosis, likely to be a result of damage by alpha particles when compared to GBMs of mice in control group.