Table 4. Gene set enrichment analysis results of significant gene sets (FDR Q<0.05) in the gene expression signature.

Gene set name	Description	NES
HALLMARK_G2M_CHECKPOINT	Genes involved in the G2/M checkpoint, as in progression through the cell division cycle	2.39
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION	Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis, and metastasis	2.34
HALLMARK_E2F_TARGETS	Genes encoding cell cycle-related targets of E2F transcription factors	2.05
HALLMARK_ANDROGEN_RESPONSE	Genes defining response to androgens	−3.62
HALLMARK_ESTROGEN_RESPONSE_EARLY	Genes defining early response to estrogen	−2.72
HALLMARK_OXIDATIVE_PHOSPHORYLATION	Genes encoding proteins involved in oxidative phosphorylation	−2.66
HALLMARK_ESTROGEN_RESPONSE_LATE	Genes defining late response to estrogen	−2.56
HALLMARK_PEROXISOME	Genes encoding components of peroxisome	−2.43
HALLMARK_FATTY_ACID_METABOLISM	Genes encoding proteins involved in metabolism of fatty acids	−2.36
HALLMARK_MTORC1_SIGNALING	Genes up-regulated through activation of mTORC1 complex	−2.13
HALLMARK_MYOGENESIS	Genes involved in development of skeletal muscle (myogenesis)	−2.07
HALLMARK_XENOBIOTIC_METABOLISM	Genes encoding proteins involved in processing of drugs and other xenobiotics	−1.84
HALLMARK_ADIPOGENESIS	Genes up-regulated during adipocyte differentiation (adipogenesis)	−1.74
HALLMARK_APOPTOSIS	Genes mediating programmed cell death (apoptosis) by activation of caspases.	−1.73

FDR: false discovery rate, NES: normalized enrichment score