Table 4. Relation of SNPs to hypertension as determined by multivariable logistic regression analysis.
| SNP | Dominant | Recessive | Additive 1 | Additive 2 | |||||
|---|---|---|---|---|---|---|---|---|---|
| P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | ||
| rs150854849 | C/T (R179Q) | 1.90 × 10−16 | 6.53 (3.79–12.41) | ND | 1.90 × 10−16 | 6.53 (3.79–12.41) | ND | ||
| rs2867125 | G/A | 0.0058 | 0.88 (0.80–0.96) | 0.4777 | 0.0076 | 0.88 (0.80–0.97) | 0.4056 | ||
| rs202069030 | G/C (R51S) | 1.01 × 10−15 | 0.15 (0.08–0.25) | ND | 1.01 × 10−15 | 0.15 (0.08–0.25) | ND | ||
| rs139012426 | G/C (S1242T) | 7.12 × 10−11 | 0.24 (0.15–0.38) | ND | 7.12 × 10−11 | 0.24 (0.15–0.38) | ND | ||
| rs75432131 | G/A (H606Y) | 0.0046 | 1.36 (1.10–1.69) | 0.2511 | 0.0065 | 1.35 (1.09–1.67) | 0.2473 | ||
| rs12229654 | T/G | 1.13 × 10−6 | 0.83 (0.77–0.90) | 0.0132 | 0.82 (0.70–0.96) | 1.44 × 10−5 | 0.84 (0.78–0.91) | 0.0014 | 0.77 (0.65–0.90) |
| rs76974938 | C/T (D67N) | 5.14 × 10−5 | 0.69 (0.57–0.82) | ND | 5.14 × 10−5 | 0.69 (0.57–0.82) | ND | ||
| rs201633733 | A/G | 0.0025 | 2.80 (1.43–5.73) | ND | 0.0025 | 2.80 (1.43–5.73) | ND | ||
| rs12352313 | A/G (N901S) | 0.0086 | 0.89 (0.81–0.97) | 0.0518 | 0.0240 | 0.90 (0.82–0.99) | 0.0394 | 0.70 (0.51–0.98) | |
Multivariable logistic regression analysis was performed with adjustment for age and sex. Based on Bonferroni's correction, P values of <1.25 × 10−4 (0.05/400) were considered statistically significant and are shown in bold. OR, odds ratio; CI, confidence interval; ND, not determined.