Table 5. Relation of SNPs to systolic or diastolic blood pressure (BP).
| SNP | Systolic BP (mmHg) | P | Diastolic BP (mmHg) | P | |||||
|---|---|---|---|---|---|---|---|---|---|
| Associated with systolic and diastolic BP and hypertension | |||||||||
| rs12229654 | T/G | TT | TG | GG | TT | TG | GG | ||
| 132 ± 24 | 130 ± 23 | 128 ± 24 | 1.16 × 10−10 | 77 ± 14 | 75 ± 13 | 75 ± 13 | 6.50 × 10−12 | ||
| Associated with systolic and diastolic BP | |||||||||
| rs671 | G/A (E504K) | GG | GA | AA | GG | GA | AA | ||
| 132 ± 24 | 130 ± 23 | 129 ± 24 | 2.32 × 10−11 | 77 ± 14 | 75 ± 13 | 75 ± 13 | 5.02 × 10−15 | ||
| rs11066015 | G/A | GG | GA | AA | GG | GA | AA | ||
| 132 ± 24 | 130 ± 23 | 129 ± 24 | 3.87 × 10−11 | 77 ± 14 | 75 ± 13 | 75 ± 13 | 7.37 × 10−15 | ||
| rs2074356 | C/T | CC | CT | TT | CC | CT | TT | ||
| 132 ± 24 | 130 ± 23 | 129 ± 24 | 9.57 × 10−10 | 77 ± 14 | 75 ± 13 | 74 ± 13 | 1.40 × 10−12 | ||
| rs3782886 | A/G | AA | AG | GG | AA | AG | GG | ||
| 132 ± 24 | 130 ± 23 | 129 ± 24 | 2.38 × 10−9 | 77 ± 14 | 75 ± 13 | 75 ± 13 | 4.40 × 10−14 | ||
| rs11066280 | T/A | TT | TA | AA | TT | TA | AA | ||
| 132 ± 24 | 130 ± 23 | 129 ± 24 | 4.71 × 10−9 | 77 ± 14 | 75 ± 13 | 75 ± 13 | 9.81 × 10−14 | ||
| Associated with systolic BP | |||||||||
| rs78010183 | A/T (T1305S) | AA | AT | AA | AT | ||||
| 132 ± 24 | 120 ± 16 | <1.0 × 10−23 | 76 ± 14 | 74 ± 12 | 0.0011 | ||||
| rs141569282 | G/A (A117T) | GG | GA | GG | GA | ||||
| 134 ± 25 | 121 ± 17 | <1.0 × 10−23 | 77 ± 14 | 74 ± 12 | 0.0002 | ||||
| rs200982668 | G/A (E2501K) | GG | GA | GG | GA | ||||
| 131 ± 24 | 120 ± 16 | 2.50 × 10−22 | 76 ± 14 | 75 ± 12 | 0.0473 | ||||
| rs61734696 | G/T (Q137K) | GG | GT | GG | GT | ||||
| 131 ± 24 | 119 ± 16 | 3.50 × 10−22 | 76 ± 14 | 75 ± 12 | 0.0303 | ||||
| rs200787930 | C/T (E1095K) | CC | CT | CC | CT | ||||
| 131 ± 24 | 119 ± 16 | 6.50 × 10−22 | 76 ± 14 | 75 ± 12 | 0.0640 | ||||
| rs139537100 | C/T (R24Q) | CC | CT | CC | CT | ||||
| 131 ± 24 | 120 ± 16 | 2.54 × 10−21 | 76 ± 14 | 75 ± 12 | 0.0449 | ||||
| rs199921354 | C/T (R80Q) | CC | CT | CC | CT | ||||
| 131 ± 24 | 120 ± 16 | 4.06 × 10−21 | 76 ± 14 | 75 ± 12 | 0.0471 | ||||
| rs188378669 | G/T (E31*) | GG | GT | GG | GT | ||||
| 131 ± 24 | 120 ± 16 | 1.40 × 10−20 | 76 ± 14 | 75 ± 12 | 0.0912 | ||||
| rs146092501 | C/T (E1386K) | CC | CT | CC | CT | ||||
| 131 ± 24 | 120 ± 16 | 2.45 × 10−20 | 76 ± 14 | 75 ± 12 | 0.0565 | ||||
| rs146879198 | G/A (R340*) | GG | GA | GG | GA | ||||
| 131 ± 24 | 120 ± 16 | 2.70 × 10−20 | 76 ± 14 | 75 ± 12 | 0.0982 | ||||
| rs115287176 | G/A (R277W) | GG | GA | GG | GA | ||||
| 131 ± 24 | 120 ± 16 | 5.08 × 10−20 | 76 ± 14 | 75 ± 12 | 0.0941 | ||||
| rs192210727 | G/T (R580I) | GG | GT | TT | GG | GT | TT | ||
| 131 ± 24 | 120 ± 16 | 118 ± 10 | 8.83 × 10−19 | 76 ± 14 | 75 ± 12 | 70 ± 11 | 0.1403 | ||
| rs199576535 | G/A (V341I) | GG | GA | GG | GA | ||||
| 131 ± 24 | 120 ± 17 | 5.70 × 10−16 | 76 ± 14 | 75 ± 14 | 0.0243 | ||||
| rs147284320 | C/T (V503I) | CC | CT | CC | CT | ||||
| 128 ± 21 | 120 ± 16 | 4.36 × 10−14 | 75 ± 12 | 75 ± 12 | 0.6346 | ||||
| rs201459911 | G/A (A1115V) | GG | GA | GG | GA | ||||
| 131 ± 24 | 143 ± 28 | 1.16 × 10−14 | 76 ± 14 | 76 ± 16 | 0.4868 | ||||
| rs199976159 | G/A (G222S) | GG | GA | GG | GA | ||||
| 131 ± 24 | 149 ± 25 | 3.98 × 10−9 | 76 ± 14 | 73 ± 15 | 0.0627 | ||||
| rs2523638 | G/A | GG | GA | AA | GG | GA | AA | ||
| 130 ± 23 | 131 ± 24 | 133 ± 25 | 7.24 × 10−8 | 76 ± 13 | 76 ± 13 | 77 ± 14 | 0.0002 | ||
| rs11191454 | A/G | AA | AG | GG | AA | AG | GG | ||
| 132 ± 24 | 130 ± 24 | 128 ± 22 | 1.43 × 10−7 | 77 ± 14 | 76 ± 13 | 75 ± 13 | 0.0032 | ||
| rs12182351 | T/C | TT | TC | CC | TT | TC | CC | ||
| 130 ± 23 | 132 ± 25 | 132 ± 24 | 2.43 × 10−9 | 76 ± 13 | 77 ± 14 | 76 ± 14 | 0.0010 | ||
| rs12413409 | G/A | GG | GA | AA | GG | GA | AA | ||
| 132 ± 24 | 130 ± 24 | 128 ± 22 | 2.03 × 10−7 | 77 ± 14 | 76 ± 14 | 75 ± 13 | 0.0029 | ||
| rs144936999 | G/C (A332P) | GG | GC | GG | GC | ||||
| 131 ± 24 | 154 ± 32 | 4.16 × 10−8 | 76 ± 14 | 76 ± 15 | 0.9989 | ||||
| rs404890 | G/T | GG | GT | TT | GG | GT | TT | ||
| 130 ± 23 | 132 ± 25 | 132 ± 24 | 7.91 × 10−9 | 76 ± 13 | 77 ± 14 | 76 ± 14 | 0.0018 | ||
| rs130075 | C/T (R102Q) | CC | CT | TT | CC | CT | TT | ||
| 132 ± 24 | 129 ± 23 | 129 ± 22 | 8.48 × 10−8 | 76 ± 14 | 76 ± 13 | 75 ± 14 | 0.0152 | ||
| rs11191580 | T/C | TT | TC | CC | TT | TC | CC | ||
| 132 ± 24 | 130 ± 24 | 128 ± 22 | 4.44 × 10−7 | 77 ± 14 | 76 ± 13 | 75 ± 13 | 0.0027 | ||
| rs1058026 | T/G | TT | TG | GG | TT | TG | GG | ||
| 132 ± 24 | 130 ± 24 | 129 ± 22 | 6.18 × 10−7 | 77 ± 14 | 76 ± 13 | 76 ± 13 | 0.1202 | ||
| rs11191548 | T/C | TT | TC | CC | TT | TC | CC | ||
| 132 ± 24 | 130 ± 24 | 128 ± 22 | 6.26 × 10−7 | 77 ± 14 | 76 ± 13 | 75 ± 13 | 0.0033 | ||
| rs2270191 | C/T (V5M) | CC | CT | TT | CC | CT | TT | ||
| 132 ± 24 | 129 ± 23 | 129 ± 22 | 4.19 × 10−7 | 76 ± 14 | 76 ± 13 | 75 ± 14 | 0.0490 | ||
| rs117951780 | C/T (S453N) | CC | CT | TT | CC | CT | TT | ||
| 132 ± 24 | 129 ± 23 | 129 ± 22 | 5.95 × 10−7 | 76 ± 14 | 76 ± 13 | 75 ± 14 | 0.0461 | ||
| rs2270190 | T/C | TT | TC | CC | TT | TC | CC | ||
| 132 ± 24 | 129 ± 23 | 129 ± 22 | 5.73 × 10−7 | 76 ± 14 | 76 ± 13 | 76 ± 14 | 0.0360 | ||
| rs17115100 | G/T | GG | GT | TT | GG | GT | TT | ||
| 132 ± 24 | 131 ± 24 | 128 ± 21 | 3.37 × 10−7 | 77 ± 14 | 76 ± 14 | 75 ± 13 | 0.0101 | ||
| rs72655343 | C/A | CC | CA | CC | CA | ||||
| 131 ± 24 | 149 ± 30 | 4.24 × 10−7 | 76 ± 14 | 77 ± 17 | 0.7231 | ||||
| rs1063646 | C/T (P133L) | CC | CT | TT | CC | CT | TT | ||
| 132 ± 24 | 129 ± 23 | 130 ± 23 | 6.24 × 10−7 | 76 ± 14 | 76 ± 13 | 76 ± 14 | 0.0473 | ||
| rs9263739 | C/T | CC | CT | TT | CC | CT | TT | ||
| 132 ± 24 | 129 ± 23 | 130 ± 23 | 6.24 × 10−7 | 76 ± 14 | 76 ± 13 | 76 ± 14 | 0.0473 | ||
| rs1004467 | T/C | TT | TC | CC | TT | TC | CC | ||
| 132 ± 24 | 131 ± 24 | 128 ± 21 | 2.28 × 10−6 | 77 ± 14 | 76 ± 14 | 75 ± 13 | 0.0208 | ||
| rs139421991 | G/A (R320Q) | GG | GA | GG | GA | ||||
| 131 ± 24 | 143 ± 28 | 6.74 × 10−7 | 76 ± 14 | 79 ± 18 | 0.0280 | ||||
| rs7757012 | T/C | TT | TC | CC | TT | TC | CC | ||
| 132 ± 24 | 129 ± 23 | 130 ± 23 | 1.02 × 10−6 | 76 ± 14 | 76 ± 13 | 76 ± 13 | 0.0526 | ||
| rs142979264 | C/T | CC | CT | TT | CC | CT | TT | ||
| 132 ± 24 | 129 ± 23 | 128 ± 21 | 3.71 × 10−6 | 76 ± 14 | 76 ± 13 | 76 ± 13 | 0.0756 | ||
| rs10849915 | T/C | TT | TC | CC | TT | TC | CC | ||
| 132 ± 24 | 130 ± 24 | 129 ± 23 | 7.27 × 10−6 | 77 ± 14 | 76 ± 13 | 75 ± 13 | 7.60 × 10−5 | ||
| Associated with diastolic BP | |||||||||
| rs7969300 | T/C (N248S) | TT | TC | CC | TT | TC | CC | ||
| 130 ± 24 | 131 ± 24 | 133 ± 25 | 0.0039 | 76 ± 14 | 76 ± 14 | 78 ± 14 | 4.59 × 10−8 | ||
| rs12231744 | C/T (R876K) | CC | CT | TT | CC | CT | TT | ||
| 131 ± 24 | 131 ± 24 | 133 ± 25 | 0.0145 | 76 ± 14 | 76 ± 14 | 78 ± 14 | 1.44 × 10−7 | ||
| Associated with hypertension | |||||||||
| rs150854849 | C/T (R179Q) | CC | CT | CC | CT | ||||
| 131 ± 25 | 133 ± 23 | 0.5574 | 76 ± 14 | 76 ± 10 | 0.7538 | ||||
| rs202069030 | G/C (R51S) | GG | GC | GG | GC | ||||
| 131 ± 24 | 131 ± 24 | 0.9913 | 76 ± 14 | 75 ± 10 | 0.6866 | ||||
| rs139012426 | G/C (S1242T) | GG | GC | GG | GC | ||||
| 131 ± 24 | 138 ± 26 | 0.1728 | 76 ± 14 | 77 ± 9 | 0.8428 | ||||
| rs76974938 | C/T (D67N) | CC | CT | CC | CT | ||||
| 131 ±25 | 132 ±19 | 0.1772 | 76 ± 14 | 75 ± 11 | 0.0291 | ||||
Data are compared among genotypes by one-way analysis of variance. Based on Bonferroni's correction, P values of <0.0005 (0.05/100) were considered statistically significant and are shown in bold.