Table 4. Multivariate analysis of associations between single-nucleotide polymorphisms (SNPs) and grade ≥ 2 radiation pneumonitis.
| SNPs | Training Cohort | Validation Cohort | Pooled analysis | ||||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| BMP2 | |||||||||
| rs170986 (CA/CC vs. AA) | 0.442 | 0.179–1.093 | 0.077 | 1.666 | 0.522–5.319 | 0.389 | 0.921 | 0.451–1.882 | 0.822 |
| rs1979855 (AG/AA vs. GG) | 0.704 | 0.221–2.244 | 0.553 | 1.873 | 0.462–7.59 | 0.379 | 1.167 | 0.480–2.837 | 0.734 |
| rs1980499 (CT/TT vs. CC) | 1.557 | 0.957–2.533 | 0.075 | 1.457 | 0.937–2.265 | 0.095 | 1.403 | 1.014–1.941 | 0.041 |
| rs235768 (AT/TT vs. AA) | 2.186 | 1.103–4.333 | 0.025 | 1.884 | 1.093–3.246 | 0.023 | 1.866 | 1.221–2.820 | 0.004 |
| rs3178250 (CT/TT vs. CC) | 0.521 | 0.251–1.081 | 0.080 | 1.107 | 0.349–3.51 | 0.863 | 0.667 | 0.362–1.230 | 0.194 |
| BMP4 | |||||||||
| rs17563 (AG/GG vs. AA) | 0.885 | 0.584–1.343 | 0.567 | 1.351 | 0.888–2.055 | 0.16 | 1.115 | 0.830–1.499 | 0.470 |
| rs4898820 (GT/TT vs. GG) | 1.347 | 0.811–2.236 | 0.25 | 0.909 | 0.584–1.415 | 0.673 | 1.115 | 0.800–1.555 | 0.521 |
| rs762642 (AC/CC vs. AA) | 1.303 | 0.753–2.254 | 0.345 | 1.006 | 0.601–1.685 | 0.982 | 1.156 | 0.794–1.682 | 0.449 |
Note: Age, Karnofsky Performance Status score, mean lung dose were used as covariates in multivariate analysis.
Abbreviation: HR, hazard ratio; CI, confidence interval.