Table 3. The three dimensions interactions of the ERCC6 rs1917799-ERCC8 rs158572-ERCC8 rs158916 with the risk of GC and CAG.
| SNP genotypes | CAG vs. CSG | GC vs. CSG | ||||
|---|---|---|---|---|---|---|
| P | OR(95%CI) | P | OR(95%CI) | |||
| ERCC6 rs1917799-ERCC8 rs158572-ERCC8 rs158916 | ||||||
| TT | AA | TT | 1(ref) | 1(ref) | ||
| TT | AA | CT/CC | 0.375 | 1.24(0.77-1.97) | 0.188 | 1.44(0.84-2.49) |
| TT | GA/GG | TT | 0.031 | 1.97(1.07-3.63) | 0.006 | 2.75(1.33-5.55) |
| TT | GA/GG | CT/CC | 0.088 | 0.23(0.04-1.25) | 0.362 | 1.74(0.53-5.72) |
| GT/GG | AA | TT | 0.718 | 1.06(0.79-1.41) | 0.013 | 1.56(1.10-2.20) |
| GT/GG | AA | CT/CC | 0.153 | 0.75(0.51-1.11) | 0.962 | 1.01(0.64-1.59) |
| GT/GG | GA/GG | TT | 0.032 | 0.61(0.39-0.96) | 0.252 | 1.33(0.81-2.20) |
| GT/GG | GA/GG | CT/CC | 0.074 | 0.27(0.07-1.14) | 0.818 | 0.86(0.24-3.10) |
| Pinteraction=0.119 | Pinteraction=0.429 | |||||
| interaction index=6.61 | interaction index=2.23 | |||||
CSG: chronic superficial gastritis; CAG: chronic atrophic gastritis; GC: gastric cancer.