Figure 6. The IL-17RC-A20 axis is critically required to selectively repress cytokine production downstream of NF-kB and JNK-c-Jun pathways.

(a) IL-17RCKD and scramble control 4T1 cell lines were cultured or stimulated with recombinant IL-17A as indicated. Cytokine ELISAs were performed using day 3 culture supernatants. (b) WT and A20KO MEFs were stimulated with or without 50 ng/ml recombinant IL-17A. Cytokine ELISAs were performed using day 3 culture supernatants. Values are presented as the mean ± SEM of 3-5 independent experiments. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; statistical analysis was compared with the pSMP vector control in panel a, or, WT cells in panel b.