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. Author manuscript; available in PMC: 2018 Jul 19.
Published in final edited form as: ACS Chem Neurosci. 2017 Mar 30;8(7):1570–1576. doi: 10.1021/acschemneuro.7b00079

Figure 1.

Figure 1

Time–concentration profiles of CNO and its metabolites after SC administration to NHPs. Plasma (A,B) and CSF (C,D) concentrations of clozapine-N-oxide (CNO; blue circles), clozapine (purple squares), and n-desmethylclozapine (NDMC; green triangles) following SC administration of CNO at 10 mg/kg (A,C) and at 3 mg/kg (B,D). In panel A, dotted lines represent blood samples obtained from conscious animals, whereas solid lines represent blood or CSF obtained under anesthesia. The data are represented as the mean and standard error of the mean (M ± SEM, n = 5); not all animals’ CSF data were included in the profiles (see Methods).

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