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. Author manuscript; available in PMC: 2018 Jul 30.
Published in final edited form as: Psychiatry Res. 2017 Apr 30;265:45–53. doi: 10.1016/j.pscychresns.2017.04.011

Table 4.

Outcome Prediction Results Using Generalized Estimating Equations: Whole Sample

FNC Coefficients for Predictor:
Unstandardized Beta; Scr
in model (No FTND)		 Coefficients for Predictor:
Unstandardized Beta; (No
Scr, No FNTD)		 Coefficients for Predictor:
Unstandardized Beta;
FTND in model (No Scr)
Hypothesized FNC Pairs Insula-dACC −0.5401 −0.97 −0.7722
p value = 0.122 p value = 0.008 p value = 0.015
Insula-dlPFC −0.237 −0.5793 −0.233
p value = 0.477 p value = 0.098 p value = 0.513

FNC = functional network connectivity. dACC=dorsolateral anterior cingulate cortex, dlPFC = dorsolateral prefrontal cortex. FTND = Fagerstrom Test for Nicotine Dependence. Scr = number of cigarettes smoked during the 60 days prior to the screen visit.

No exploratory FNC pairs had significant coefficients using a Bonferroni correction (p<0.004); exploratory FNC pairs with sub-threshold significant findings (0.05>p>0.004) are in supplemental materials. Because the interaction term [FNC value * treatment group assignment (varenicline versus placebo; TrGrp)] was not significant for any of the models, results for models without the interaction term are presented.

TrGrp and head motion (rmsRot) were included in all models, but coefficients are not listed here for simplicity. TrGrp, FTND, and Scr were significant predictors in all models, and rmsRot was not a significant predictor in any of the models.

1

Standardized betas: Scr = 0.356(p<0.001), TrGrp = −0.180, rmsRot = −0.042, Insula-dACC=−0.105

2

Standardized betas: FTND = 0.327(p<0.001), TrGrp = −0.0211, rmsRot = −0.067, Insula-dACC = −0.151

3

Standardized betas: TrGrp = −0.194, rmsRot = −0.053, insula-dlPFC = −0.127