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. 2017 Apr 15;8(25):40486–40500. doi: 10.18632/oncotarget.17119

Figure 5. IDO1 deficiency reduced IL-17a and downstream cytokines during Liver fibrosis.

Figure 5

(A) Quantitative real-time PCR analysis to detect IL-17a mRNA in the liver tissues of WT and IDO1–/– mice. (B) Western blot analysis of the expression of IL-17a in the livers of WT and IDO1–/– mice. (C) Immunofluorescence analysis to detect the expression of IL-17a in the livers of WT and IDO1–/– mice. (D) ELISA evaluating the serum IL-17a level in mice. (E) Western blot analysis of the expression of STAT3 in the livers of WT and IDO1–/– mice. (F) Quantitative real-time PCR analysis to detect IL-6, TGF-β1, TNF-α and IL-1β mRNA in the liver tissues of WT and IDO1–/– mice. The data are presented as the means ± SEM (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).