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Green: mutations known or assumed to be activating; red: loss of function mutations; blue: mutations in the TERT promoter region; grey: missense mutation (frequently with unknown functional consequences); brown: wild-type samples (showing no mutation in the analyzed gene panel). Tumor location: Yellow, genital area; light pink, anorectum; dark blue, head and neck; light green, urinary tract; petrol, digestive tract; grey, data missing.
