Figure 2. Glibenclamide remitted acute radiation-induced liver injury of mice.

1 hour before irradiation, BABL/C mice received intraperitoneal injection of glibenclamide (10mg/kg). On the first, third and fifth day the livers of mice (n=5) were taken to (A, C) make histopathological analysis by H&E staining (micrographs in A; quantified in C; Magnification x 200) and blood were collected to (E) measure serum ALP level. The mice livers taken on Day 3 (n=5) were detected apoptosis by (B, D) dUTP nick-end labeling (TUNEL) assay (micrographs in B; quantified in D; Magnification × 400) and (F) electron microscopic observation. Arrows represent cytopathic sites. Data were presented as mean± SD. *P<0.05.