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. 2017 Mar 27;8(25):40872–40884. doi: 10.18632/oncotarget.16606

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Copyright: © 2017 Cao et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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αMSH reduced Foxo1 through MC5R, then down-regulated Bim and up-regulated Rictor, which inhibited apoptosis via mTORC2. Foxo1 is a transcriptional activator of Bim and can aggravate ROS-induced apoptosis by binding to Bim promoter region in adipocytes.