Figure 5. Correlations between expression levels of DNA repair genes in clinical samples.
A. Correlations between gene expression levels of MRE11A/MLH1 and MRE11A/ERCC8 using the TCGA dataset of HGS tumors. Bars represent percent of patients in each category: double negative, single positive or double positive biomarkers staining. B. Upper panel shows representative images of IHC scores (0, 1, 2, 3) for MLH1 or MRE11A staining. Bottom panel shows correlation between expression levels of MLH1 and MRE11A proteins in a TMA containing patients’ samples of HGS EOC.