Table 2. Deregulated DNA repair pathways between Olaparib sensitive and resistant cell lines.

Cell line	DNA repair ingenuity canonical pathways	p-value	Upregulated genes	Downregulated genes
OV2295	NHEJ	0.0035	DCLRE1C, LIG4
OV4453	MMR	0.045	RPA1	EXO1
TOV1946	MMR	5.25e-10		MLH1, FEN1, RFC3, EXO1, POLD1, PCNA, RFC1, RFC5, MSH6, RFC4, MSH2
	HR	4.68e-07		BRCA1, POLA1, RAD50, ATM, RPA1, LIG1, RAD51, ATRX, MRE11A, NBN
	NHEJ	6.92e-06		PARP1, RAD50, XRCC5, ATM, XRCC4, DCLRE1C, MRE11A, LIG4, NBN
TOV3041G	HR	8.51e-06	LIG1, RAD51	BRCA1, RAD50, ATRX, MRE11A, NBN
	NHEJ	1.15e-04		RAD50, XRCC4, DCLRE1C, MRE11A, LIG4, NBN
	MMR	0.015		RFC3, MSH6, MSH2
OV1946	MMR	6.61e-10		MLH1, FEN1, RFC3, EXO1, MSH6, RFC5, POLD1, RFC4, PCNA, MSH2
	HR	0.0074		RPA1, RAD51, ATRX, MRE11A, NBN
	NHEJ	0.0074		PARP1, XRCC4, MRE11A, LIG4, NBN
	NER	0.044		POLR2B, RPA2, POLR2J, POLR2C, POLR2I, POLR2K