Table 3. Quantification of Olaparib sensitivities (IC₅₀) in EOC cell lines upon gene downregulation of the selected genes by siRNA.

siRNA		Olaparib IC50 (µM)
		Control	Scr	MRE11A	MLH1	MLH3	ERCC8	MRE11A /MLH1	MRE11A /ERCC8	MLH1 /ERCC8
Resistant	OV1369(R2)	21.71 ±10.33	21.03 ±6.44	2.18 ±0.19	2.44 ±0.13	5.66 ±2.50	2.74 ±0.48	0.03 ±0.02	0.08 ±0.03	0.80 ±0.06
	OV866(2)	8.11 ±1.27	6.04 ±1.10	1.53 ±0.40	1.94 ±0.29	3.57 ±0.76	1.85 ±0.41	0.01 ±0.005	0.05 ±0.02	1.10 ±0.70
Intermediate	TOV2295(R)	1.52 ±1.14	1.43 ±0.42	0.26 ±0.07	0.34 ±0.15	0.66 ±0.30	0.88 ±0.11	0.11 ±0.08	0.09 ±0.06	0.20 ±0.07
	OV4485	0.90 ±0.58	1.18 ±0.07	0.73 ±0.40	0.08 ±0.04	0.30 ±0.05	0.21 ±0.08	0.06 ±0.01	0.06 ±0.004	0.08 ±0.02
Sensitive	OV1946	0.07 ±0.05	0.04 ±0.02	N/A	0.05 ±0.01	0.03 ±0.003	N/A	N/A	N/A	N/A
	TOV3041G	0.02 ±0.01	0.03 ±0.005	N/A	N/A	N/A	0.03 ±0.004	N/A	N/A	N/A