Figure 14. Contribution of macroautophagy and chaperone-mediated autophagy in the malignant transformation and HCC growth in cirrhotic liver.
Macroautophagy serves as a tumor suppressor in hepatocytes in the cirrhotic liver. Macroautophagy loss promotes HCC. CMA compensate for the impaired macroutophagy for HCC survival in the cirrhotic liver.