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. 2017 Feb 2;8(25):41572–41581. doi: 10.18632/oncotarget.15017

Figure 2. Enzyme kinetics of glucuronidation of SN-38 by UGT1A1.

Figure 2

Michaelis-Menten graph of SN-38G formation when different concentrations of SN-38 were incubated with belinostat (0, 10, 100 and 200 μmol/L) A. Apparent intrinsic clearance of SN-38G B. By using a paired t-test, the incubations with 100 and 200 μmol/L belinostat were significantly different (p < 0.05) from the incubation without belinostat (*).