Table 3. Summary of the effects of drug treatment on cell cycle progression in MOLT4 cells.
Condition | G0/G1 | S-Phase | G2/M | SubG1 |
---|---|---|---|---|
DMSO | 40.0 ± 3.2% | 27.1 ± 2.5% | 25.0 ± 3.1% | 7.9 ± 1.4% (0%) |
100 μM TMZ | 41.0 ± 4.1% | 19.8 ± 1.5% | 21.4 ± 2.4% | 17.8 ± 2.5% (9.9%) |
10 μg/mL 3-Eth-5-NIdR | 40.8 ± 3.9% | 23.1 ± 3.2% | 21.5 ± 2.1% | 14.6 ± 1.9% (6.7%) |
Combination | 34.8 ± 2.5% | 18.9 ± 1.9% | 15.4 ± 1.5% | 30.9 ± 2.9% (23.0%) |
Values represent an average of three (3) independent determinations performed on different days. Values in parentheses represent the difference in percent sub-G1 DNA measured with various treatments compared to treatment with DMSO (vehicle control).