Table 2. Results of univariate and multivariate analyses for predictors of PFS, whole cohort.

	Univariate Analysis			Multivariate Analysis
	HR (95% CI)		p value	HR (95% CI)		p value
Age at diagnosis	0.992	(0.987−0.998)	0.012	0.989	(0.983−0.995)	< 0.0005
Gender (Ref = Female)
Male	1.359	(1.190−1.550)	< 0.0005	1.355	(1.186−1.547)	< 0.0005
Ethnicity (Ref = Others)
Chinese	1.048	(0.72−1.525)	0.806	1.047	(0.717−1.529)	0.810
Japanese	0.678	(0.448−1.026)	0.066	0.796	(0.525−1.209)	0.285
Korean	0.952	(0.651−1.392)	0.800	1.162	(0.79−1.708)	0.446
Smoking history (Ref = Never smoker)
Ever smoker	1.228	(1.059−1.425)	0.007	−		−
Stage (Ref = Relapse)
IIIA/B	1.583	(1.201−2.087)	0.001	1.523	(1.147−2.022)	0.004
IV	1.412	(1.175−1.699)	< 0.0005	1.455	(1.201−1.762)	< 0.0005
Histology (Ref = Adenocarcinoma)
Non-adenocarcinoma	1.590	(1.203−2.101)	0.001	1.832	(1.381−2.433)	< 0.0005
EGFR phenotype (Ref = Sensitizing)
Resistant	2.551	(1.972−3.300)	< 0.0005	2.705	(2.067−3.542)	< 0.0005
Line of treatment (Ref = Later)
First-line	1.152	(1.010−1.313)	0.035	−		−
ECOG status (Ref = 0 or 1)
≥ 2	1.284	(0.997−1.653)	0.053	1.408	(0.898−2.209)	0.136
BIM deletion (Ref = Absent)
Present	1.323	(1.108−1.581)	0.002	1.406	(1.174−1.684)	< 0.0005