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. 2017 Mar 29;8(25):40037–40051. doi: 10.18632/oncotarget.16673

Figure 9. LAListat-2 reduces lipid mediator release in peritoneal macrophages.

Figure 9

Thioglycolate-elicited macrophages were loaded with acLDL (100 μg protein/ml, 6 h) in the absence or presence of the pharmacological LAL inhibitor LAListat-2 (10 μM, 6 h). A. Cholesterol concentrations, B. neutral CE hydrolase activity, and lipid mediators derived from C. COX, D. LOX, E. LOX/CYP, and F. COX/CYP pathways. Lipid mediator concentrations were determined by LC-MS/MS analysis. Data are presented as (A, B) means (n = 7-9) + SD and E.-F. median and range (n = 6). n.d., not detectable. *p < 0.05.