Table 2. Meta-analysis of short and long-term outcomes.
Outcome of interest | Studies | Participants | OR/WMD | 95% CI | P-value | I2 (%) |
---|---|---|---|---|---|---|
Clinicopathologic features | ||||||
Male gender | 3 | 1231 | 0.58 | 0.46, 0.75 | <0.001 | 0 |
Age | 4 | 1470 | 0.10 | -1.28, 1.47 | 0.10 | 40 |
Body mass index | 2 | 695 | -0.26 | -1.26, 0.74 | 0.62 | 0 |
Preoperative anemiaa | 2 | 775 | 2.51 | 1.83, 3.45 | <0.001 | 0 |
ASA > 2 | 2 | 748 | 1.15 | 0.59, 2.24 | 0.69 | 76 |
Extended or major resection | 4 | 1470 | 1.64 | 1.28, 2.09 | <0.001 | 0 |
Duration of surgery (min) | 2 | 775 | 55.64 | 42.14, 69.14 | <0.001 | 0 |
Blood loss (mL) | 4 | 1470 | 726.88 | 376,91, 1076.84 | <0.001 | 93 |
Tumor size (cm) | 2 | 695 | 0.95 | -0.13, 2.03 | 0.09 | 78 |
Tumor number | 2 | 695 | -0.03 | -0.49, 0.44 | 0.90 | 59 |
Negative surgical margin | 4 | 1470 | 1.03 | 0.70, 1.51 | 0.89 | 0 |
Postoperative outcomes | ||||||
Overall morbidity | 6 | 2833 | 1.98 | 1.49, 2.33 | <0.001 | 51 |
Major complication | 4 | 2226 | 2.12 | 1.26, 3.58 | 0.005 | 76 |
Mortality | 5 | 2821 | 4.13 | 1.96, 8.72 | <0.001 | 51 |
Length of stay (day) | 3 | 2099 | 4.42 | 1.15, 7.69 | 0.008 | 82 |
Long-term outcomes | ||||||
Overall survival | 21 | 8732 | 1.24 | 1.11, 1.38 | 0.0002 | 71 |
Disease-free survival | 11 | 5018 | 1.38 | 1.23, 1.56 | <0.001 | 17 |
Abbreviations: OR=odds ratio, WMD=weighted mean difference, CI= confidence interval,
ASA= American Society of Anesthesiologists