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. Author manuscript; available in PMC: 2018 Jul 21.
Published in final edited form as: Circ Res. 2017 May 17;121(3):258–269. doi: 10.1161/CIRCRESAHA.117.311054

Figure 1. PVM, juxtaposed to penetrating cerebral blood vessels, are depleted by clodronate.

Figure 1

In WT mice (non-transgenic littermates) injected with PSB-liposome (vehicle), PVM identified by phagocytized dextran (green) are closely apposed to penetrating neocortical vessels, identified by the lipophilic dye DiO (red) (A). PVM in Tg2576 mice injected with vehicle have numbers and distributions similar to WT mice (B). Intracerebroventricular (icv) administration of clodronate-containing liposomes depletes PVM both in WT and Tg2576 mice 5 days later (C,D). Quantification of the number of PVM in WT and tg2576 mice after icv injection of liposomes containing PBS or clodronate (E). No differences between WT and Tg2576 mice are observed. *p<0.05 from PBS; n=5/group; Analysis of variance and Tukey’s test.