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. Author manuscript; available in PMC: 2018 Jul 21.
Published in final edited form as: Circ Res. 2017 May 17;121(3):258–269. doi: 10.1161/CIRCRESAHA.117.311054

Figure 2. PVM depletion prevents the cerebrovascular effects of neocortical superfusion of Aβ1-40 in WT mice.

Figure 2

In WT mice treated with PBS liposomes, superfusion of the somatosensory cortex with Aβ1-40 (5μM) attenuates resting CBF (A), and the increase in CBF evoked by whisker stimulation (B), or by neocortical application of ACh (10μM) (C), but not adenosine (400μM) (D). Treatment with clodronate does not affect baseline cerebrovascular responses, but rescues the attenuation in resting CBF and CBF responses to whiskers stimulation and ACh induced by Aβ1-40 superfusion. Furthermore, clodronate suppresses the Aβ-induced increase in cerebrovascular ROS in the somatosensory cortex, assessed by DHE microfluorography (E). LDU, arbitrary laser-Doppler perfusion units; RFU, relative fluorescence units; *p<0.05 from vehicle, ANOVA and Tukey’s test; n=5/group.