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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: J Cell Physiol. 2017 Apr 12;232(12):3520–3529. doi: 10.1002/jcp.25812

Figure 3. Tissue injury in placentas of E.18 d SERT- and TPH1-KO and WT mice placentas.

Figure 3

Figure 3

Figure 3

(A) TUNEL assay performed in placentas of these mice. Note the uneven (patchy) TUNEL staining. The images in each panel are acquired at 200X magnification. (B) Quantification of the TUNEL. The apoptosis in placentas from SERT-KO mice were 65-fold higher than WT, 6-fold higher than the rates of placentas from TPH1-KO mice. (C) Quantification of the proliferation marker Ki67 mean intensity. The images in each panel are acquired at 400X magnification. No difference was seen on the proliferation rates of placentas from transgenic or WT mice. TUNEL assay and Ki67 staining were performed on 10 slides per placenta, 6 placentas from each mouse, n=4. Asterisks indicate statistical difference between WT and SERT-KO (*) mice P<0.05 assessed by one way ANOVA and a Bonferroni post hoc test. The scale bars represent 10 μm.