Table 2.
The effects of NGM on antibiotic susceptibility of S. aureus MR23 in Mueller–Hinton or BHIG broth
| Antibiotic | Mueller–Hinton | BHIG | ||||
|---|---|---|---|---|---|---|
| MIC* (μg/mL) | MIC (μg/mL) | |||||
| Control | NGMa | 17DNb | Control | NGM | 17DN | |
| β-lactam | ||||||
| Oxacillin | 32 | 4 | 4 | 8 | 0.5 | 0.5 |
| Ampicillin | 8 | 0.25 | 4 | 4 | 0.25 | 0.25 |
| Cefazolin | 16 | 1 | 4 | 4 | 1 | 1 |
| Cefmetazole | 16 | 8 | 16 | 8 | 2 | 2 |
| Flomoxef | 8 | 1 | 4 | 4 | 1 | 1 |
| Cefoxitin | 16 | 8 | 16 | 16 | 8 | 8 |
| Imipenem | 2 | 0.25 | 0.25 | 0.25 | 0.03 | 0.06 |
| Glycopeptide | ||||||
| Vancomycin | 2 | 1 | 1 | 2 | 2 | 2 |
| Teicoplanin | 2 | 1 | 1 | 2 | 1 | 1 |
| Oxazolidinone | ||||||
| Linezolid | 2 | 2 | 2 | 4 | 2 | 2 |
| Aminoglycoside | ||||||
| Gentamicin | 4 | 2 | 2 | >8 | >8 | >8 |
| Arbekacin | 0.5 | 0.25 | 0.25 | 2 | 1 | 1 |
| Tetracycline | ||||||
| Minocycline | <2 | <2 | <2 | <2 | <2 | <2 |
| Macrolide | ||||||
| Erythromycin | 0.25 | 0.25 | 0.25 | 0.5 | 0.5 | 0.5 |
| Lincomycin | ||||||
| Clindamycin | <0.06 | <0.06 | <0.06 | 0.12 | 0.12 | 0.12 |
| Fosfomycin | ||||||
| Fosfomycin | <32 | <32 | <32 | 32 | 64 | 64 |
| Fluoroquinolone | ||||||
| Levofloxacin | >4 | >4 | >4 | 4 | 4 | 4 |
| Sulfonamide | ||||||
| Sulfamethoxazole–Trimethoprim | <10 | <10 | <10 | 40 | 20 | 20 |
In these experiments, cells were cultured under biofilm-forming conditions, with 50 μM of the test compound
*Minimum inhibitory concentration
a Norgestimate
b 17-deacetyl norgestimate