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. 2017 Jul 21;7:6171. doi: 10.1038/s41598-017-06275-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Reduction of inflammation, fibrosis and galectin-3 was found in the hearts of DMS-treated mice. (A) Experimental design of in vivo treatment. C57BL/6 mice infected with trypomastigotes (Colombian strain) were treated during the chronic phase of infection (6 months pos-infection) with DMS (200 µg/Kg/day; 3x week; i.p.). (B) Microphotographs of heart sections stained with hematoxylin and eosin or sirius red or anti-galectin-3 (1:50; red) and DAPI (blue). (C) Inflammatory cells were quantified in heart sections of naive mice, saline-treated chagasic mice, or DMS-treated chagasic mice and integrated by area. (D) The expression of CD45 was evaluated by real-time qRT-PCR using cDNA samples prepared from mRNA extracted from hearts of experimental groups. (E) Fibrotic area is represented by percentage of collagen deposition in heart sections. (F) Quantifications of galectin-3⁺ cells in heart sections were performed in ten random fields captured under 400x magnification, using the Image Pro Plus v.7.0 software. Bars represent means ± SEM of 10 mice/group. ***P < 0.001; **P < 0.01; *P < 0.05 compared to saline group; ^# P < 0.05 compared to naive group.