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. 2017 Jul 21;7:6134. doi: 10.1038/s41598-017-06463-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Actin localization at the area of stiffness in the cell. (A) Actin localization in living HUVECs was visualized by Lifeact-EGFP and the cellular stiffness of the actin-localized part of HUVECs was measured (n = 3). Actin localization (left panel) and Young’s modulus image (center panel) are shown. Both images of actin localization and the Young’s modulus were merged (right panel). Scale bar showing 10 μm. (B) Young’s modulus images of HUVECs treated with 10 μM blebbistatin and/or TNF-α for 4 hours are shown. (C) The Young’s modulus of control group (n = 5), blebbistatin group (n = 5), TNF-α group (n = 5), and TNF-α and blebbistatin group (n = 6). Representative data from two experiments are shown. *P < 0.05, **P < 0.01; measured using a Tukey’s test followed by two-way ANOVA.