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. 2017 Jul 21;7:6100. doi: 10.1038/s41598-017-06258-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Volume of the hyper-intense signal measured on the in vivo 3D WS-bSSFP images within the bone defects filled with the 3 biomaterials over weeks 1, 3 and 5. (b) BV/TV measurements from the ex vivo Micro-CT scans analysis. NS: Non Significant differences. Significant differences between biomaterials at each week are indicated with *p < 0.05 and **p ≤ 0.01 for week 3 and ^##p ≤ 0.01 for week 5. Of note, the MRI volumes measured in Matrix-HA-Fuco filled defects were significantly different to each other at every time point. The MRI volumes measured in Matrix-HA filled defects at week 1 was significantly different to the ones obtained at week 3 and week 5. Similarly, the MRI volumes measured in Matrix-Fuco filled defects at week 5 was significantly different to the one obtained at week 1.