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. 2017 Jul 21;7:6189. doi: 10.1038/s41598-017-06537-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Time profile of nisin titer (square), cell density (circle) and pH (triangle) of L. lactis F44 cultured in DSM medium (hollow symbols) and commercial medium (solid symbols). Average data of triplicate experiments were presented. Error bars represent standard deviations from three parallel replicates. The data were analyzed by One-way ANOVA. Statistically significant differences between DSM medium groups and commercial medium groups were indicated by for *p < 0.05 for **p < 0.01 and for ***p < 0.001.