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. 2017 Jul 21;7:6174. doi: 10.1038/s41598-017-06351-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NER is not required for expression of AREG and EREG. Using lentiviral transfection stable knockdown of XPA (A), ERCC4 (XPF) (D), and ERCC5 (XPG) (G) was achieved in Panc1-2G6 (low α6β4) and Panc1-3D7 (high α6β4) cells as confirmed by QPCR. AREG and EREG expression was examined following knockdown in cells with both low α6β4 (B,E,H) and high α6β4 (C,F,I) expression. Data depicted are representative of at least three different experiments and represent the mean +/− standard deviation. Statistical significance was calculated using a one-tailed t-test in which * denotes P < 0.05 as compared to controls.