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. 2017 Jul 21;7:6167. doi: 10.1038/s41598-017-06435-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative single-channel current trace reflecting the PAMAM-G1 – α-HL interactions in 0.5 M KCl, at pH = 7. In panel a we show a typical electrophysiology trace reflecting the PAMAM-G1 – α-HL reversible blockades recorded at ΔV = +100 mV, in 0.5 M KCl and pH = 7, and the corresponding all-events histogram. The dendrimer (500 μM) was added on the trans side of the recording chamber. The zoomed-in trace in the inset depicts the blockade amplitude (ΔI_block) and the corresponding duration (τ_off), for a single PAMAM-G1 – α-HL interaction event. In panel b we illustrate the ΔI_block vs. ΔV dependence (‘’ – ‘up-filled squares’) and that of the relative current blockade (ΔI_block/I_o) vs. ΔV (‘’ – ‘right-filled squares’).

Inline graphic — Representative single-channel current trace reflecting the PAMAM-G1 – α-HL interactions in 0.5 M KCl, at pH = 7. In panel a we show a typical electrophysiology trace reflecting the PAMAM-G1 – α-HL reversible blockades recorded at ΔV = +100 mV, in 0.5 M KCl and pH = 7, and the corresponding all-events histogram. The dendrimer (500 μM) was added on the trans side of the recording chamber. The zoomed-in trace in the inset depicts the blockade amplitude (ΔI_block) and the corresponding duration (τ_off), for a single PAMAM-G1 – α-HL interaction event. In panel b we illustrate the ΔI_block vs. ΔV dependence (‘’ – ‘up-filled squares’) and that of the relative current blockade (ΔI_block/I_o) vs. ΔV (‘’ – ‘right-filled squares’).