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. 2017 Jul 21;7:6167. doi: 10.1038/s41598-017-06435-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The kinetics description of PAMAM-G1 – α-HL interactions in 0.5 M KCl, at pH = 7. Representative histograms of the inter-event (τ_on) (panel a) and blockade duration intervals (τ_off) (panel b) characterizing the PAMAM-G1 – α-HL interactions recorded at ΔV = +100 mV, in 0.5 M KCl, at pH 7, with the trans-side added dendrimer (500 μM). The histograms were fitted with mono-exponential functions, and corresponding reaction rates describing the PAMAM-G1 – α-HL interactions were derived. The dendrimer capture rate by the nanopore (rate_on, ‘’ – ‘down-filled squares’), and the dissociation rate (rate_off, ‘’ – ‘up-filled squares’) are shown in panel c. The voltage-dependence of inter-event times (τ_on) and blockade durations (τ_off) are shown in panels d (‘’ – ‘down-filled squares’) and e (‘’ – ‘up-filled squares’).

Inline graphic — The kinetics description of PAMAM-G1 – α-HL interactions in 0.5 M KCl, at pH = 7. Representative histograms of the inter-event (τ_on) (panel a) and blockade duration intervals (τ_off) (panel b) characterizing the PAMAM-G1 – α-HL interactions recorded at ΔV = +100 mV, in 0.5 M KCl, at pH 7, with the trans-side added dendrimer (500 μM). The histograms were fitted with mono-exponential functions, and corresponding reaction rates describing the PAMAM-G1 – α-HL interactions were derived. The dendrimer capture rate by the nanopore (rate_on, ‘’ – ‘down-filled squares’), and the dissociation rate (rate_off, ‘’ – ‘up-filled squares’) are shown in panel c. The voltage-dependence of inter-event times (τ_on) and blockade durations (τ_off) are shown in panels d (‘’ – ‘down-filled squares’) and e (‘’ – ‘up-filled squares’).