Table 3. Fold change of genes identified for regulation of skeletal extension and growth, is presented as treated vs. control during daytime, night-time and without treatment.

Their fold change p-values are indicated in brackets.

Clone ID	Annotation/Gene match name	Fold change C11 vs. C23 (p-value)	Fold change (T11 vs. C11) (p-value)	Fold change (T23 vs. C23) (p-value)	Functional classification
SMAD1	Mothers against decapentaplegic homolog 1	−1.5 (ns)	2.9 (1.6E−05)	1.7 (0.004)	SMAD protein complex assembly
SMAD2	Mothers against decapentaplegic homolog 2	−1.2 (ns)	2.7 (2.9E−07)	1.8 (5.1E−05)
SMAD3	Mothers against decapentaplegic homolog 3	−1.1 (ns)	2.05 (1.5E−05)	1.4 (0.004)
BMP1	Bone morphogenetic protein 1	−1.05 (ns)	2.3 (0.001)	1.8 (ns)	Cartilage & Bone Biogenesis
CTNNB1	Catenin (Cadherin-associated protein) beta−1	−1.06 (ns)	2.2 (0.001)	1.9 (0.006)
COL2A1	Collagen alpha-1(II) chain	−2.04 (0.009)	2.1 (0.01)	−1.3 (ns)
WNT5B	Protein Wnt-5b	−1.2 (ns)	2.3 (1.6E−05)	1.2 (ns)
EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3	−1.08 (ns)	2.2 (2.9E−07)	1.7 (1.4E−05)
ADAMTS2	A disintegrin and metalloproteinase with thrombospondin motifs 2	−1.05 (ns)	3.2 (2.9E−05)	1.4 (ns)
ADAMTS7	A disintegrin and metalloproteinase with thrombospondin motifs 7	−1.3 (ns)	2.0 (1E−04)	1.05 (ns)
LRP4	Low-density lipoprotein receptor-related protein 4	−1.1 (ns)	2.6 (9.5E−06)	1.8 (5E−04)
FGFR1	Fibroblast growth factor receptor 1	−1.1 (ns)	2.1 (1.6E−06)	1.1 (ns)
PAX7	Paired box 7 transcription factor	1.1 (ns)	2.3 (0.003)	1.4 (ns)

Notes.

ns indicates for ‘not significant’.