Fig. 2.

Expansion of GMPs influenced by various pathologic insults. Percentage of GMPs (defined as Lineage (Lin)⁻Sca-1⁻ckit⁺CD16/32⁺CD150⁻) within the Lin⁻Sca-1⁻ckit⁺ fraction of the bone marrow of the following groups of mice: non-tumor-bearing (NTB) wild-type (n = 19), IRF8^−/− (n = 3), 4T1 (n = 14) or AT-3 (n = 8) tumor-bearing (>250 mm³), or NTB wild-type mice following treatment with recombinant G-CSF protein (10 µg/day for 5 days; n = 5). Data compiled from multiple experiments. *P < 0.01 as determined by an unpaired t test