Table 1.
Patients’ demographic and clinicopathological characteristics
| Characteristic | n | 1–10 ELNs (%) | 11–20 ELNs (%) | 21–30 ELNs (%) | >31 ELNs (%) | p-value |
|---|---|---|---|---|---|---|
| Age (years) | ||||||
| Median ± SD | 43.0±12.2 | 44.0±13.1 | 43.0±12.3 | 43.0±11.7 | 42.0±11.0 | <0.001 |
| Year of diagnosis | ||||||
| 1988–1999 | 3,005 | 484 (20.4) | 1,045 (23.7) | 818 (27.0) | 658 (32.8) | <0.001 |
| 2000–2013 | 8,825 | 1,890 (79.6) | 3,373 (76.3) | 2,216 (73.0) | 1,346 (67.2) | |
| Ethnicity | ||||||
| White | 9,417 | 1,823 (76.8) | 3,530 (79.9) | 2,445 (80.6) | 1,619 (80.8) | <0.001 |
| Black | 1,030 | 286 (12.0) | 383 (8.7) | 227 (7.5) | 134 (6.7) | |
| Other | 1,302 | 250 (10.5) | 472 (10.7) | 337 (11.1) | 243 (12.1) | |
| Unknown | 81 | 15 (0.6) | 33 (0.7) | 25 (0.8) | 8 (0.4) | |
| Grade | ||||||
| G1 | 1,542 | 298 (12.6) | 582 (13.2) | 405 (13.3) | 257 (12.8) | 0.435 |
| G2 | 4,532 | 887 (37.4) | 1,716 (38.8) | 1,157 (38.1) | 772 (38.5) | |
| G3–4 | 4,005 | 806 (34.0) | 1,472 (33.3) | 1,020 (33.6) | 707 (35.3) | |
| Unknown | 1,751 | 383 (16.1) | 648 (14.7) | 452 (14.9) | 268 (13.4) | |
| FIGO stage | ||||||
| IA2 | 1,573 | 348 (14.7) | 653 (14.8) | 372 (12.3) | 200 (10.0) | <0.001 |
| IB NOS | 4,746 | 883 (37.2) | 1,685 (38.1) | 1,241 (40.9) | 937 (46.8) | |
| IB1 | 4,015 | 769 (32.4) | 1,571 (35.6) | 1,057 (34.8) | 618 (30.8) | |
| IB2 | 767 | 187 (7.9) | 257 (5.8) | 185 (6.1) | 138 (6.9) | |
| IIA | 729 | 187 (7.9) | 252 (5.7) | 179 (5.9) | 111 (5.5) | |
| Histological type | ||||||
| SCC | 7,920 | 1,557 (65.5) | 2,952 (66.8) | 2,030 (66.9) | 1,361 (67.9) | 0.760 |
| AC | 3,910 | 797 (33.5) | 1466 (33.2) | 1004 (33.1) | 643 (32.1) | |
| Radiotherapy | ||||||
| Yes | 8,205 | 1,522 (64.1) | 3,110 (70.4) | 2,161 (71.2) | 1,412 (70.5) | <0.001 |
| No | 3,625 | 852 (35.9) | 1308 (29.6) | 873 (28.8) | 592 (29.5) | |
| Marital status | ||||||
| Unmarried | 5,065 | 1,015 (42.8) | 1,909 (43.2) | 1,332 (43.9) | 809 (40.4) | 0.001 |
| Married | 6,326 | 1,264 (53.2) | 2,316 (52.4) | 1,604 (52.9) | 1,142 (57.0) | |
| Unknown | 439 | 95 (4.0) | 193 (4.4) | 98 (3.2) | 53 (2.6) | |
| Number of PLNs (n) | ||||||
| 0 | 10,018 | 2,021 (85.1) | 3,772 (85.4) | 2,558 (84.3) | 1,667 (83.2) | <0.001 |
| 1 | 853 | 175 (7.4) | 307 (6.9) | 230 (7.6) | 141 (7.0) | |
| 2 | 442 | 106 (4.5) | 159 (3.6) | 108 (3.6) | 69 (3.4) | |
| 3 | 214 | 31 (1.3) | 88 (2.0) | 53 (1.7) | 42 (2.1) | |
| >4 | 303 | 41 (1.7) | 92 (2.1) | 85 (2.8) | 85 (4.2) |
Abbreviations: AC, adenocarcinoma; ELNs, examined lymph nodes; FIGO, International Federation of Gynecology and Obstetrics; G1, well differentiated; G2, moderately differentiated; G3, poorly differentiated; G4, undifferentiated; NOS, not otherwise specified; PLNs, positive lymph nodes; SCC, squamous cell carcinoma; SD, standard deviation.