TABLE 1.
Study characteristics and description of the feasibility outcomes from the exercise interventions
| Study | Sample size |
Intervention characteristics (mode, duration, supervision, sets, reps, load) |
Overall findings | Recruitment rate,% |
Retention rate,% |
Adherence rate,% |
Adverse events |
|---|---|---|---|---|---|---|---|
| Battaglini32 | 20 | 15 wk of supervised RE; 2–3 sets of 6–12 reps at 40%–60% 1RM | Improvements in muscular strength and fatigue | na | 100 | na | No events reported |
| Battaglini20 | 20 | 15 wk of supervised RE+AE; 2–3 sets of 6–12 reps at 40%–60% 1 RM, 6–12 min AE | Improvements in lean body mass, body fat, and strength | na | 100 | na | No events reported |
| Cadmus29 | 6 mo of home-based AE; 150 min/wk, 60%–80% AP-MHR | Improvements in depression and happiness | 64 | No events reported | |||
| Chandwani28 | 132 | 6 wk of yoga 3 d/wk during radiation | Improvements in QoL, fatigue, sleep quality, and depression | 55 | 69 | na | No events reported |
| Courneya22 | 242 | RE: Supervised for duration of chemo, 2 sets of 8–1 2 reps at 60%–70% 1RM. AE: Supervised 3 d/wk, 15–45 min, 60%–80% VO2max. | RE yielded improvements in upper- and lower-body strength. Both exercise groups had a higher completion rate of chemotherapy, compared with control group. | 33 | 92.1 | 72 (AE) 68 (RE) | 2 mild/moderate events involving nausea, dizziness and weakness |
| Dolan23 | 242 | RE: Supervised for duration of chemo, 2 sets of 8–1 2 reps at 60%–70% 1RM. AE: Supervised 3 d/wk, 15–45 min, 60%–80% VO2max. | Participants in both groups experienced decline in hemoglobin regardless of intervention. RE and AE interventions maintained VO2max throughout treatment. | 33 | 92 | 72 (AE) 68 (RE) | 2 mild/moderate events involving nausea, dizziness and weakness |
| Hornsby16 | 20 | 12 wk of supervised AE, 3 d/wk, 15–45 min, 60%–100% VO2peak | Improvements in social well-being. Non-significant improvements in VO2peak and QoL. | 73 | 95 | 66 | 1 mild/moderate involving leg pain during AE |
| Husebø25 | 67 | Home-based RE+AE: RE: total body exercises 3 d/wk AE: 30 min/d light-vigorous intensity | Increase in fatigue at completion of chemo, with return to baseline at 6-mo follow-up. Improvement in 6MWT and MET at 6-mo follow-up. | 72 | 76 | 58 | 1 mild/moderate event involving knee discomfort |
| Hwang26 | 40 | 5 wk mixed AE+RE 50 min, 3 d/wk | Improvement in QoL | na | 92.5 | na | No events reported |
| Kim30 | 41 | 8-wk supervised AE, 3 d/wk, 30 min, 60%–70% VO2peak | Improvement in VO2peak and voluntary exercise | na | 55 | 78.3 | No events reported |
| Mock31 | 52 | Home-based walking intervention for duration of treatment, 150 min/wk, 50%–70% AP-MHR | Participants in High Walkers group experienced improvements in fatigue, activity level, and aerobic capacity compared with participants in Low Walkers group. | na | 70 | No events reported | |
| Mock19 | 119 | Home-based walking intervention for duration of treatment, 150 min/wk, 50%–70% APM-HR | Participants in High Walkers group experienced in improvements in 12MWT and physical activity compared with Low Walkers group. | 50.8 | 90 | 72 | No events reported |
| Schmidt21 | 95 | 12-wk RE intervention, 3 sets, 8–12 reps, 60%–80% 1RM | RE resulted in negligible changes in fatigue, QoL, depression, and cognitive function. | na | 96 | 71 | No events reported |
| Schwartz24 | 66 | RE: Home-based for duration of treatment, 2 sets 8–10 reps. AE: Home-based 4 d/wk, 15–30 min, moderate intensity. | RE yielded improvements in leg extension and seated-row 1RM. AE yielded improvements in 12MWT, leg extension, and seated-row 1RM. | 95 | 93 | n/a | No events reported |
| Vadiraja27 | 88 | 6-wk supervised yoga, 60 min, 3 d/wk | Improvements in anxiety, stress, depression, and 6 am Cortisol levels | 53.3 | 63.6 | na | No events reported |
| Wang17 | 72 | 6-wk home-based AE intervention, 10–30 min, 3–5 d/wk, 40%–60% AP-MHR | Improvements in QoL, sleep, ESE, GLTEQ score | 45 | 80.6 | 93.6 | No events reported |
| Yang18 | 40 | 6-wk supervised AE intervention, 20–30 min, 2–3 d/wk, 40%–65% AP-MHR | Improvements in MET, and MDSAI and POMS scores | na | 90.9 | 77 | No events reported |
AE, aerobic exercise; AP-MHR, age-predicted maximal heart rate; ESE, exercise stress echocardiography; GLTEQ, Godin Leisure-Time Exercise Questionnaire; MDSAI, MD Anderson Symptom Inventory; MET, metabolic equivalent task; min, minute; mo, month; MWT, minute walk test; na, not applicable; POMS, Profile of Mood States; RE, resistance exercise; RM, repetition maximum; VO2, oxygen consumption; QoL, quality of life; wk, week