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. Author manuscript; available in PMC: 2017 Jul 23.
Published in final edited form as: J Orthop Res. 2016 Jul 8;35(4):876–885. doi: 10.1002/jor.23342

Figure 1.

Figure 1

Proposed mechanism of action of the peptide CK2.1 based on previous data.5 (A) Schematic demonstrates the known mechanism of BMP2-mediated BMPRIa activation described according to the literature as follows: (1) Ligand binding to the BMPRIa and BMPRII receptor complex leads to the (2) release of CK2 allowing for phosphorylation of (3) downstream signaling. (B) Schematic illustrates the possible mechanism of peptide through the activation of BMPRIa downstream signaling as follows: (1) Peptide CK2.1 blocking of CK2 interaction to BMPRIa leads to (2) downstream signaling.