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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Virology. 2017 May 4;508:7–17. doi: 10.1016/j.virol.2017.04.029

Figure 4. PMA increases tax/rex RNA stability in inducible HTLV-1 T Cell Lines.

Figure 4

HTLV-1 infected FS (A), SP (B) and HUT102 (C) cells were treated with PMA for 30 min, washed, then treated with Act D, and RNA decay assays were performed. Tax/rex mRNAs were measured with splice site-specific primers (closed circle: untreated, open circle: PMA treated). Similar to results observed in FS cells, PMA also increased the tax/rex RNA stability in SP cells. In contrast, in HUT102 cells, which constitutively express high levels of Tax protein, PMA fails to change the RNA degradation rate.