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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Neurobiol Dis. 2017 Apr 11;105:273–282. doi: 10.1016/j.nbd.2017.04.010

Figure 2.

Figure 2

Three genes encoding kinesin-1 subunits are expressed in mammalian nervous system: kinesin-1A (KIF5A), kinesin-1B (KIF5B), and kinesin-1A (KIF5C). Antibodies that selectively recognize each one of these subunits (Deboer et al., 2008) reveal a unique distribution pattern for each subunit in different regions of the central nervous system, suggesting that different neurons display a unique complement of conventional kinesin heavy chain subunit variants: Br whole brain; ON optic nerve; SC spinal cord; SN sciatic nerve; OB olfactory bulb, CCX cerebral cortex; HIP hippocampus; and CB cerebellum. Note that kinesin-1A is widely expressed in nervous tissue, but that there are quantitative differences in different regions. Kinesin-1B and kinesin-1C show more variability among brain regions. This and other observations imply cell type-specific specializations of axonal transport rarely recognized in the literature, which may contribute to the selective vulnerability of specific neuronal populations in different AONDs.