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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Biochem J. 2016 Aug 31;473(21):3951–3964. doi: 10.1042/BCJ20160606

Figure 4. RyR2-SOF mutant mice are more susceptible to APD alternans.

Figure 4

Hearts from the RyR2-WT and RyR2-SOF mutant mice were perfused with oxygenated Tyrode’s buffer containing 1.8 mM Ca2+ . After the heart rate became stable, rapid pacing was applied to trigger APD alternans. Representative traces of monophasic action potential (MAP) recordings from RyR2-WT (A) and RyR2-SOF heart (B) paced at 8 Hz are shown. Panel (C) shows APD alternans in RyR2-WT and RyR2-SOF hearts at different pacing frequencies (5 to 10 Hz). Data shown are mean ± SEM (n=3 hearts for each group) (*p<0.05 and **p<0.01).