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. 2017 Jun 7;23:134–148. doi: 10.2119/molmed.2016.00188

Figure 8.

Figure 8.

(A)Fasudil reverses LPS-induced vascular leakage and ROS production. Fasudil has an EC50 of 3.852 μM. (B, C) Fasudil mitigates LPS-induced vascular leakage and the resulting leakage of FITC-dextran and its accumulation at the tail fin (an average of 3 trials of 10 larvae/treatment). (D, E) Fasudil also rescued LPS-induced ROS production at the tail fin (an average of 3 trials of 3 larvae/treatment) and (F) LPS-induced reduction of ROS in the swim bladder (an average of 3 trials of 3 larvae/treatment).