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. 2017 Apr 28;84:54–61. doi: 10.1016/j.curtheres.2017.04.004

Table III.

Change from baseline in Wisconsin Upper Respiratory Symptom Survey (WURSS-21) scores (modified intent-to-treat population).

Guaifenesin/pseudoephedrine (n = 591) Placebo (n = 588) P value*
Overall total WURSS-21 score
 Mean change from baseline to Day 4 40.0 36.4 0.024
 Mean change from baseline to Day 8 68.0 65.4 0.085
Total WURSS-21 symptom score
 Mean change from baseline to Day 4 19.4 17.7 0.013
 Mean change from baseline to Day 8 33.4 32.0 0.165
Total WURSS-21 functional score
 Mean change from baseline to Day 4 16.2 14.6 0.050
 Mean change from baseline to Day 8 27.7 26.8 0.056

Difference between treatment groups in change from baseline is based on ANCOVA with treatment, region, baseline total WURSS-21 functional score, antibiotic use, and treatment by antibiotic use terms in the model.