Table I.
Population | n | Dose | Sampling plan | Basic pharmokinetic model | Reference |
---|---|---|---|---|---|
Japanese | 13 women, 21 men | 14 g ethanol (350 mL beer)10 min in the fasted state | 5, 10, 20, 30, 60 min postdose | 1 compartment | 11 |
Chinese | 36 women, 31 men | 36† and 56‡ g ethanol | 1.5, 2, 2.5, 3, | 1 compartment | 10 |
Indian | 43 women, 44 men | 200† and 300‡ mL (mixture of vodka and orange juice) 1 h with a meal | 3.25, 3.5, 3.75, 4, 4.25, 4.5, 4.75, 5, 6 h postdose | Michaelis-Menten elimination |