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Results of the biochemical p53/Hdm2 competition assay for stapled Hdm2‐binding peptides and their linear counterparts
| Biochemical assay | IC50 Hdm2 ± SD (nM)a | |
|---|---|---|
| 1a | cis | 0.15 ± 0.04 |
| 1b | trans | 0.19 ± 0.05 |
| 2a | cis | 0.17 ± 0.06 |
| 2b | trans | 0.23 ± 0.08 |
| 3 | linear 1 | 0.45 ± 0.05 |
| 4 | linear 2 | 0.46 ± 0.08 |
| Nutlin‐3a | – | 8.0 ± 1.5 |
Means ±SD from at least three independent experiments.
